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Title:Effects of 8 Weeks of Endurance Training on the Concentration of 6-IL, Insulin in Male Rats Authors: Behrooz Yazdani; Rezvan Dadkhah; Mahtab Firozeh; HosseinFallah Azad Boni; MahbobehMohammadi DOI: Aff: Department of physical Education ,Central Tehran Branch, Islamic Azad University, Tehran, Iran Author Email: Keywords: Male Rats;Insulin;Plasma Levels;Skeletal Muscle;Muscle Cells;Wistar Rats;Hypothesis Test;Plasma Insulin URLs:ABSTRACT-HTML | FULLTEXT-PDF | Abstract:Skeletal muscle has the expression capacity of several cytokines, including IL-6, 8 and 15, together are called Myokine. In 2008, Handschin and Spiegelman have recognised the Myokines as the cytokines produced by the muscle cells that show the relationship between sport and inflammation Methodology: As long as the subjects of the different groups of this research were rats, which were in a controlled environment and at a pre and post planned test, under the effects of independent variable (8-week exercise program), so the research method is experimental. In the present research, after the initial agreement, fourteen 3-month-old male Wistar rats were obtained from the Pasteur Institute Centre of Amol. Variables measured in the exercise and control groups were compared and then the descriptive and inferential statistics were used to analyse the hypothesis test. Natural distribution of data measured by the Kolmogorov Simonov test, and the statistical analysis of the data performed using the software SPSS version 16 by the ANOVA test through repeated measurements based on the normal distribution. To compare variables between the two groups of the t test was used. The significant level for all calculations was considered as p <0.05. Resalts: According to table (1) and the independent t test significance level, the zero hypothesis is rejected. Therefore, eight weeks of endurance exercise has a significant impact on plasma levels of IL-6 in male rats (p 0.005). There are significant differences in the concentrations of plasma insulin of rats with and without exercise. According to table and the amount of t and independent t test significance level, the zero hypothesis cannot be rejected. Therefore, eight weeks of endurance exercise has no significant impact on plasma levels of insulin in male rats (p 0.005).