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Title: The Effect of the Stress Hormone Corticosterone and ACTH Concentrations Swimming and Surgery in Mature Male Sprague-Dawley Rats
Authors: Solhjoo Kavous; Kargar Jahromi Hossein; Kargar Jahromi Zahra; Farzam Mohammad; Azhdari Sara; Mahmoudi Teimourabad Saeid
DOI:
Aff: Zoonosis Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Author Email: kargarjahromy@yahoo.com
Keywords: Swim Stress; Surgical Stress; ACTH; Corticosterone
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Abstract:Introduction: The number of stress hormones and neurotransmitter systems of the body and cause activation of the pituitary - adrenal (HPA) and the sympathetic system in the body. Corticosterone, glucocorticoid in the rat adrenal cortical secretion in part is influenced by stress. ACTH-secreting pituitary adrenal also found that the stress concentration changes can affect the secretion of corticosterone. This study compared the effects of chronic stress hormone ACTH and corticosterone swimming and surgery in male rats. Methods: in this experimental study, 40 adult male rats of Sprague-Dawley rats were used. Animals were randomly divided into 4 groups as follows: Control, stress, swimming, surgery, surgery plus swim stress. Animal groups and surgical stress swimming with swim stress for 7 consecutive days, each day for 10 minutes in water at 25 C were swimming. In the surgical group, a length of one centimeter incision in the back and the lumbar vertebrae 5-3 were created. The results of the statistical software SPSS version 18 and the surface P =0.05 was LSD test was used for comparisons between groups. Results: Swim stress alone caused a significant increase in ACTH. Chronic stress caused a significant increase in the concentration of corticosterone was swimming with surgery. Discussion: Swimming chronic stress may increase ACTH and corticosterone by the HPA axis is activated