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Title:The Effect of Hydroalcoholic Extract of Artemisia (Artemisia Herba-Alba) and Markers of Liver Damage Compared with Metformin in Streptozotocin-Induced Diabetic Rats Authors: Kouhpeyma Farhad; Kargar Jahromi Hossein; Zahiri Shahla; Azhdari Sara; Farzam Mohammad; Mahmoudi Teimourabad Saeid DOI: Aff: Department of Histology, International branch, Shiraz University, Shiraz, Iran. Author Email: email@example.com Keywords: Diabetes; Liver; Rat; Artemisia; Histopathology; ALT and AST URLs:ABSTRACT-HTML | FULLTEXT-PDF | Abstract:Introduction: Studies indicate that Artemisia extract caused a significant decrease in glucose levels in diabetic animals. The aim of this study was to investigate the effect of Artemisia plant extracts to improve diabetes complications and markers of liver damage, it is. Materials and Methods: 40 rats, adult female Wistar rats randomized to the following groups for 56-day treatment groups (control, sham, diabetic (streptozotocin 55mg/ kg), diabetic + extract of Artemisia (200 and 300 mg/kg), diabetic + metformin 250 mg/kg control and extract Artemisia (200 and 300 mg/kg). beginning and end of the experiment, body weight and blood glucose in rats was measured, and then to measure ALT and AST of mice were bled after dissection, the liver removed and fixed in 10% formalin and cutting and preparing for special studies were conducted respectively. Data editing software spss statistics 15 and Duncan test were analyzed. The results indicate an increase in blood sugar, necrosis, granulation and inflammatory lymphocytes in the liver and increased liver enzymes ALT and AST in the diabetic group and decreased in the diabetic group treated are the groups received the extract of Artemisia alone a significant increase in ALT levels was observed compared to controls (p = 0.05). Conclusion: The results of this study show that hydroalcoholic extract of Artemisia can significantly reduce the complications of diabetes brought on liver but its use is not recommended for the average person that is because in some cases it has harmful effects on consumers should receive careful consideration.