Page: 56-61 ------------------------------> Last_modified :12/31/2015 1:12:00 AM
Title:Plasma Testosterone and Testis Histological Features of Mice Treated with Averrhoa Bilimbi, Cosmos Caudatus and Pereskia Bleo Ethanolic Extract Authors: Marysia Julius Booh; Nur Hilwani Ismail; Dzulsuhaimi Daud ; Noorain Hashim DOI: Aff: School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan Author Email: Keywords: Plasma Testosterone; Testis Histological Features; Averrhoa Bilimbi; Cosmos Caudatus; Pereskia Bleo URLs:ABSTRACT-HTML | FULLTEXT-PDF | Abstract:Averrhoa bilimbi (AB), Cosmos caudatus (CC) and Pereskia bleo (PB) are among the local plants in Malaysia enriched with plant secondary compounds scientifically proven to contain high value in medical pharmacology. This study involving these three selected plants was conducted to analyses the plasma testosterone concentration and testis histological features of mice supplemented with four different concentrations (50, 125, 500 and 1000 mg/kg b. wt) of AB, CC and PB ethanolic extract. There was a significant reduction in plasma testosterone level across all AB treatment groups (177.83▒0.03pg/ml, 266.07▒0.05pg/ml, 281.84▒0.03pg/ml and 277.07▒0.00 pg/ml, respectively) compared to control group (515.82▒0.01pg/ml), in both 50 and 500mg/kg b. wt of CC (546.39▒0.03pg/ml and 728.62▒0.04, respectively), and in 50, 125 and 1000mg/kg b. wt of PB ethanolic extracts (375.84▒0.05pg/ml, 865.96▒0.03pg/ml and 473.15▒0.01pg/ml, respectively). All concentrations of AB extract (206.77▒5.51ým, 194.29▒4.25ým, 202.92▒3.34ým and 207.34▒6.34ým, respectively) and 50 and 500 mg/kg b. wt of PB extract (212.30▒5.57ým and 214.70▒4.31ým, respectively) seem to reduce the diameter of seminiferous tubules, while comparing to the control (236.81▒7.07ým). The lumen diameter in the seminiferous tubules also decreases in 125mg/kg b. wt of AB (70.14▒3.09ým), 1000mg/kg b. wt of CC (73.47▒2.80ým) and in the 50 and 125 mg/kg b. wt of PB extracts (72.65▒3.99ým and 78.54▒3.85ým, respectively). The spermatogenic cells in Figure1: C1, B2, C2, D2, E2, B3, C3 and E3 were packed and improved as compared to Figure 1A. The degeneration of spermatocyte and spermatogonia layer was also observed (Figure 1: B1, C1, D1, E1, D2, B3, C3, D3 and E3).